Respected physician John Dolittle swaps human patients for animal ones as his parrot Polynesia teaches him the secret of talking to the animals. His fame spreads and he travels to Africa to treat a monkey epidemic. Setting out with his favorite crew of creatures, Dolittle must face trial after trial; being shipwrecked, escaping the king of Jolligingki and figuring out what do do with a pushmi-pullyu, the shy two-headed gazelle-unicorn cross.

Doctor Dolittle, a little, lovable old doctor, had so many animal pets spread throughout his house and garden that patients would not come to him anymore. As a result, he became poorer and poorer.

But Doctor Dolittle occupied nearly all of his time tending to his pets, and his fame as an animal doctor spread all over the world. When the monkeys in Africa were stricken with an epidemic, they gave the good doctor a call. He set sail at once.

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